Organic synthesis

Synthesis and chemical transformations of coumarins

 


 

Head of the group

Assoc. Professor Dr Anka Bojilova

Tel: +3592-8161428; Fax: +3592-9625438

abojilova@chem.uni-sofia.bg

 

Group members

Assistant Professor Dr Rositca Nikolova

          rnikolova@chem.uni-sofia.bg

Nevena Petkova, Ph.D. student

          npetkova@abv.bg

 

 

 


Selected publications

Chr.Ivanov, A.Bojilova

“Umwandlung von 2-Oxo-2H-1-benzopyran-3-carbonsaure-estern in 2-Oxo-4-chromanessigsaureester - eine neue Umlagerung” Chem.Ber. 111 (1978) 3755.

A.Bojilova, C.Ivanov

“Synthesis of the nitrile and some esters of 3,3-dimethyl-2-oxochroman-4-acetic acid” Synthesis  (1986) 415.

A.Bojilova, C.Ivanov

“Thermal transformation of some 3-acyl-2-oxo-2H-1-benzopyrans with acid anhydrides” Indian J.Chem. 26B (1987) 731.

A.Bojilova, T.Kostadinova, C.Ivanov

“Interaction of nitromethane with esters and amides of 2-oxo-2H-1-enzopyran-3-carboxylic acid” Synth.Communications 19 (1989) 2963.

A.Bojilova, T.Kostadinova, C.Ivanov

“Allylation-assisted addition of nitromethane to 3-substituted 2H-1-benzopyran-2-ones” Liebigs Ann.Chem. (1989) 1041.

A.Bojilova, N.Rodios, R.Nikolova, C.Ivanov

“On the reaction of 3-acylsubstituted 2H-1-benzopyran-2-ones with acid anhydrides Part II” Liebigs Ann. Chem. (1991) 1279.

A.Bojilova, N.Rodios, R.Nikolova, C.Ivanov

“On the reaction of 3-acylsubstituted 2H-1-benzopyran-2-ones with acid anhydrides promoted by potassium fluoride. An improve methode for the synthesis of 4-(2-oxoalkyl)-2-oxochromanes. Part III” Synth. Communications, 22 (1992) 741.

A.Bojilova, N.Rodios, A.Trendafilova, C.Ivanov

“Cyclopropanation reaction of 3-acyl-2H-1-benzopyran-2-ones with phenacylbromide in Phase transfer systems” Tetrahedron, 49 (1993) 2275.

N.A.Rodios, A.Bojilova, A.Terzis, C.P.Raptopoulou

“Reaction of 3-nitro- and 3-diethylphosphonocoumarin with phenacyl bromide. X-Ray molecular structure of 3-nitro-3,4-phenacilidenecoumarin” J.Heterocyclic Chem., 31 (1994) 1129.

A.Bojilova, N.A.Rodios, I.Videnova, A.Terzis, C.P.Raptopoulou

“Regio- and stereoselective 1,3-dipolar cycloaddition reactions of ethyl diazoacetate to 3-substituted 2H-1-benzopyran-2-ones” Tetrahedron, 50 (1994) 13023.

A.Bojilova, R.Nikolova, C.Ivanov N.A.Rodios, A.Terzis, C.P.Raptopoulou

“A comparative Study of Interaction of Salicylaldehydes with Phosphonoacetates under Knoevenagel Reaction Conditions. Synthesis of 1,2-Benzoxaphosphorines and their Dimers” Tetrahedron, 52 (1996) 12597.

R.Nikolova, A.Bojilova, N.Rodios

“Reaction of 3-bromobenzyl and 3-bromoacetyl coumarin with phosphites. Synthesis of some new phosphonates and phosphates in the coumarin series” Tetrahedron 54 (1998) 14407.

 

 

International cooperation

 

·    Prof. N.A.Rodios, Aristotle University of Thessaloniki, Greece

Research interests

 

·    Investigations on the chemical reactivity of the substituted in the position 3 with electronwithdrawing groups 2-oxo-2H-1-benzopyrans (coumarins) towards nucleophilic reagents.

·    In the reactions with organomagnezium and organozinc reagents.

·    The interaction with CH-acidic compounds by the action of some bases.

·    In the condition of the Perkin reaction 3-acylsubstituted coumarins participate in a new benzopyran – 2-oxochroman rearrangement. The mechanism of these transformations and its relation of the reaction conditions are studied.

 

·    Synthesis and the chemical transformations of some phosphorus containing coumarin derivatives with potentional .biological activity.

·    By the reactions of Ch-acidic phosphonates with 2-hydroxybenzaldehydes.

·    In the reactions of some coumarin derivatives with phosphates